Effect of leaf extract and fractions of Solanum anomalum on oxidative stress markers, kidney function indices and histology of alloxan-induced diabetic rats

In ethnomedicine, the leaf of S. anomalum is used to treat a variety illnesses, including diabetes. The goal this study was assess effects extract and fractions on kidney function indices, renal histology, indicators oxidative stress in rats with diabetes caused by alloxan. Antioxidative renoprotective potentials (70-210 mg/kg) (140 were assessed determining markers levels, parameters histopathology alloxan-induced diabetic rats. levels (Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), glutathione (GSH) significantly increased (p<0.05–0.001), while level MDA lowered treated high serum urea creatinine (p<0.05–0.001) reduced fractions, whereas electrolytes not decreased . histology either showed no pathological abnormalities or considerable reduction features. findings suggest antioxidative nephroprotective capabilities Solanum which may be result antioxidant activities their phytochemical constituents